anti smooth muscle antibody

In some cases, additional time should be Any side effects will be mild and may include bruising around the insertion site or light-headedness. Although it is said that the test is rather non-specific for liver diseases, ASMA is found in up to 70% of people who have type 1 autoimmune hepatitis. Anti-smooth muscle antibodies are antibodies ( immunoglobulins) formed against smooth muscle. Anti-Smooth Muscle Antibody; ASMA; F-Actin Antibody; SMA; F-Actin (Smooth Muscle) Antibody, IgA. i had this test a while back and i was feeling very ill, i was positive but i believe it was fairly low, i was tested witht he same test a few weeks later and it was negative, the notes show this normally proves its somthing viral and not to do with the liver (i have had all other tests for liver and is fine now). Anti-smooth muscle Myosin heavy chain 11 antibody [EPR5335] (ab124679) Research with confidence - consistent and reproducible results with every batch. This may be taken through a vein. Antibodies with Advanced . My gp did a liver function test and ALT was a bit raised up but that . The fetal red blood cells have just . In the patient with acute HBV, rheumatoid factor was the NOSA detected and in the patient with acute CMV, hepatitis E IgM was the FPA detected. All rights reserved. [1][2], These antibodies can be directed against actin, troponin, and tropomyosin. This may be taken through a vein. $ 429.00. Actin (Smooth Muscle) Antibody (IgG) - Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. These antibodies are typically associated with autoimmune hepatitis. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. Clinical. Actin (Smooth Muscle) Antibody (IgG) - Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. Antibody Prevalence Anti-neutrophil cytoplasmic antibody 50%-80% Anti-nuclear antibody 7%-77% Anti-smooth muscle antibody 13%-20% Anti-endothelial cell antibody 35% Anti-cardiolipin antibody 4%-66% Thyroperoxidase 7%-16% Thyroglobulin 4% Rheumatoid factor 15% HEPATOLOGY, Vol. The results of an ASMA test are either normal or abnormal. moonlightin. Because of its anti-spasmodic action on smooth muscle is an aid in therapy [.] They will insert a needle into the vein and draw the necessary amount of blood. These results can suggest that a person has: When ASMA levels are high, a doctor will likely request further tests to determine the cause. This antibody could be used together with anti-muscle specific actin, myogenin in making a diagnosis of smooth muscle, skeletal muscle tumors. They will remove the arm band and place an adhesive bandage over the site. An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. This includes reflex and additional tests. In general, patients with definite autoimmune hepatitis have median serum titers of ASMA and ANA of 1:160 and 1:320, respectively. The ASMA test can help a doctor to diagnose autoimmune disorders in the liver and other conditions. Anti-smooth muscle antibodies (ASMAs) attack several structural proteins in smooth muscle, affecting the liver and other tissues.. Anti-smooth muscle antibody is a blood test that detects the presence of antibodies against smooth muscle. I am a healthy 38yr old male who did have viral Hepatitis at the age of 13. The presence of ASMA in the blood indicates that a person may have autoimmune hepatitis or another disease that damages the liver. Sera from patients with Type 1 chronic active . A 35-year-old female asked: Miscarriage at 7 weeks with little c antibody titer level 1:512. did little c cause miscarriage? Request A Test offers the convenient and affordable Anti Smooth Muscle Antibody Test in Vineland, NJ.This test measures the level of Actin Smooth Muscle Antibodies (ASMA) in the blood. Anti-Smooth Muscle Antibody Alternative name: ASM SMA: Description: A rather non-specific test. The smooth muscle antibody (SMA) test is usually requested with antinuclear antibodies (ANA) to help diagnose autoimmune hepatitis. Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added, Detection of antibodies aids in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). A smooth muscle actin antibody helps tag myoepithelial cells, myofibroblasts, and ordinary smooth muscle cells. Also, different labs may return different values. During the test, a technician draws blood from a vein in the arm, taking the following steps: A person will likely feel a slight pinch when the technician inserts the needle. Immunologic detection. Details. Anti-smooth muscle antibody is a blood test that detects the presence of antibodies against smooth muscle. Smooth Muscle Antibody, IgG Titer Feedback I want to provide feedback regarding - Select - Missing or Incorrect Test Information Test Research Assistance Other Test Content Questions Pricing and Availability General Usability of Test Directory Look and Feel of Test Directory Request a New Feature in Test Directory Limitations. Preparation. These antibodies can be directed against actin, troponin, and tropomyosin. It had been assumed that in all of these conditions the anti-smooth muscle antibody bound the . Hi, I have come to know that my antibodies blood test came back and the anti smooth muscle antibody is positive. Follow. Other autoantibodies, such as liver-kidney microsomal type 1 (LKM1) antibodies and antimitochondrial antibodies (AMA), may also be used to help diagnose autoimmune liver disease and distinguish it from other causes . Cells were fixed with 4% PFA for 15 min at room temperature and permeabilizated by 0.5% Triton X-100. Choose from 1 of 39 Alpha-Smooth Muscle Actin antibodies, which have been validated in experiments with 878 publications and 315 images featured in our data gallery. Smooth Muscle Actin Antibody (CGA7) is a mouse monoclonal IgG 2b κ, cited in 106 publications, provided at 200 µg/ml; raised against full length gizzard Actin of chicken origin; Smooth Muscle Actin Antibody (CGA7) is recommended for detection of α and γ Actin isotypes of smooth muscle cells of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; non cross-reactive with . This antibody is usually related to autoimmune hepatitis. Normal results indicate that a person has either none of the antibodies in their blood or only a trace amount. These antibodies are usually of two types: immunoglobulin G (IgG) and immunoglobulin M (IgM). Doctors use a blood test to check for these antibodies. If ASMA levels are high, the doctor may request additional testing before making a diagnosis and recommending a course of treatment. Smooth muscle antibody. After determining why ASMA levels are high, the doctor will confirm and explain the diagnosis and develop a treatment plan. Antiactin antibodies have been reported at low levels in 3% to 18% of sera from the general healthy population. Email. Anti-smooth muscle antibodies are antibodies (immunoglobulins) formed against smooth muscle. Find the Alpha-Smooth Muscle Actin antibody that fits your needs. Specimen. An ASMA test is carried out in the same way as any routine blood test. Anti-smooth muscle antibodies are antibodies (immunoglobulins) formed against smooth muscle. Test . This may be taken through a vein. Learn about the test and what its results mean. The technician will remove the needle and apply pressure to the insertion site. Anti-smooth muscle antibody is a blood test that detects the presence of antibodies against smooth muscle. Background: The presence of anti-smooth muscle autoantibody (SMA) in Autoimmune Hepatitis (AIH) is well established. Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls. Cell Culture Supernatant (dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3). Antibodies. The antibody is sensitive to the alpha actin form of . The technician will tie an elastic band around the middle of the upper arm, making the veins more visible. The antibody is useful in making a diagnosis of autoimmune hepatitis. Actin antibodies are found in 52% to 85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis. Species: Human, Rat, and Broad Species Reactivity. Certain health conditions, including liver disease and hepatitis, cause the immune system to produce anti-smooth muscle antibodies. It is done to check for liver disease if other symptoms like unexpected weight loss…, Cirrhosis is a liver condition that causes irreversible scarring on the liver. These indicate that a person has higher amounts of ASMA in their blood. Smooth Muscle Antibody. The accurate diagnosis and classification of autoimmune hepatitis (AIH) rely upon the detection of characteristic autoantibodies. Result LOINC. hi i have a question aboutt the blood test for smooth muscle antibody (ASMA). Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. I'm confused. COVID-19: Do vaccines protect better than infection-induced immunity? The medical community considers results to be abnormal when the amount of ASMA in the blood sample corresponds to a titer of greater than 1:40. Anti Smooth Muscle Antibody worriedperson38. Detected by chemiluminescence. Between 20% and 30% of patients with NAFLD . Mouse anti human actin alpha (smooth muscle) antibody, clone 1A4 recognises alpha smooth muscle actin. A blood sample is needed. Autoimmune hepatitis is an unresolving inflammation of the liver of unknown etiology that is associated with high concentrations of autoantibodies, pronounced hypergammaglobulinemia and the absence of cholestasis. A lab technician will analyze the levels of ASMA in the blood and return results. These smooth muscle antibodies were found in a variety of conditions, including infectious diseases, rheumatic disorders, and malignancies. You have 3 more open access pages. It can lead to scarring, liver failure, and other…, Glandular fever, or infectious mononucleosis, stems from a viral infection. I want to provide feedback regarding Comment. Alpha-smooth muscle actin is a 42 kDa protein and is a major component of the cytoskeletal structural network. Alpha smooth muscle actin is expressed in vascular smooth muscle, myofibroblasts and myoepithelial . Anti-Smooth Muscle Ab by IFA. [7, 10] At present, IIF is still the standard method used to detect anti-smooth-muscle antibodies (ASMAs).This technique involves subjecting thin specimens of rodent liver, stomach, or kidney to a patient's serum. This is when the autoantibodies trespass the body's cells. Anti-Actin, α-Smooth Muscle antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the 1A4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the NH2 terminal synthetic decapeptide of a smooth muscle actin, coupled to keyhole limpet hemocyanin (KLH). Enzyme-linked immunosorbent assay (ELISA). The presence of immune complexes in the patient's sample may produce false positives in this assay. Autoantibodies are antibodies made by . nws-obgyn.com. Find out about its causes, symptoms, and treatment…. A blood sample is needed. 661 In contrast, these titers may be in the range of 1:80 or less in . Cell lysates were stained with ARG66381 anti-alpha smooth muscle Actin antibody [SQab18108] at 1:2000 dilution, overnight at 4°C. Last Name. parfarm.com.mx. Anti-alpha smooth muscle Actin Antibody (A82445) (1µg/ml) staining of Rat Heart lysate (35µg protein in RIPA buffer). An autoantibody attacks the body's own cells and tissues by mistake. Anti-muscle-specific kinase (anti-MuSK) antibodies are autoantibodies, proteins produce by the immune system that mistakenly attack proteins called muscle-specific kinases.This test detects these autoantibodies in the blood of people with myasthenia gravis (MG), a rare but often severe autoimmune disease that causes muscle fatigue and weakness. (2) SMAs are generally identified by indirect immunofluorescence using a smooth muscle substrate. 5358-7. © 2021 Laboratory Corporation of America® Holdings. I have been reading about it and I am slightly worried. Anti-F-actin is an antibody targeted at actin, a specific cytoskeletal protein. Antibodies are usually produced by the body to fight off illnesses and infections. A smooth muscle antibody (SMA) is a type of antibody known as an autoantibody. Anti-smooth muscle antibodies were first discovered in 1965 in patients with chronic active hepatitis [ 1 ]. The earliest experiments for detection of smooth-muscle antibodies involved indirect immunofluorescence (IIF). The antibodies attack the smooth muscle in a person’s body. nws-obgyn.com. Smooth muscle antibodies (SMA) are autoantibodies, proteins produced by the body's immune system that recognize and attack its own actin, a protein found in smooth muscle and other tissues, especially the liver.This test detects and measures the amount (titer) of SMA (or antibody against actin) in the blood. The antibody is useful in making a diagnosis of autoimmune hepatitis. The full-length protein is 42,009 daltons in mass and has been noted to be cytoplasmic. Antiactin antibodies have been reported at low levels in 3% to 18% of sera from the general healthy population. Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls. Any discomfort will usually fade after a few seconds. The definitive diagnosis requires the exclusion of viral, hereditary and drug induced liver disease. Smooth Muscle Ab: Smooth muscle antibody measurements are useful in confirming the diagnosis of chronic active hepatitis (CAH). Combatting Modern Slavery and Human Trafficking Statement. Clean eating: What does the research say? 51, No. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for SKU: 4629-MSM3. The antibody is useful in making a diagnosis of autoimmune hepatitis. Formulation. An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Smooth muscle antibodies are usually negative in extrahepatic biliary obstruction, drug induced liver disease, viral hepatitis and hepatoma. Anti-smooth muscle antibodies (ASMAs) attack several structural proteins in smooth muscle, affecting the liver and other tissues. Check with a doctor about necessary preparations, such as fasting, though the ASMA test does not usually require any. Client ID. A change in diet may reduce risk of lethal prostate cancer, Regularly consuming fish may protect brain health, Everything you need to know about cirrhosis. The person will sit with an arm resting on a table. (2) Because the . Immunofluorescence: NRK-49F cells treated with TGF beta 1 (10 ng/ml) for 0~48 hours. These antibodies are typically associated with autoimmune hepatitis. ASMA (antibody targeting rodent stomach smooth muscle structures) was initially found in the serum of patients with lupoid hepatitis and It was frequently detected with anti-nuclear antibody positivity (ANA) [ 7 ]. The definitive diagnosis requires the exclusion of viral, hereditary and drug induced liver disease. It requires a liver biopsy to establish the diagnosis. . Learn more >>>. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Leiomyosarcomas are positive only with anti-muscle specific . Please Select Product Options Below To View The Catalog Number. Result Code Name. parfarm.com.mx. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). The ASMA test is a low-risk procedure similar to any routine blood test. Alpha smooth muscle actin antibody (ab5694) stains smooth muscle cells in vessel walls, gut wall, and myometrium. 1-800-522-2787 Email . F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Sera from patients with Type 1 . Please note: not all lab locations offer all services. © 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved. The antibody is useful in making a diagnosis of autoimmune hepatitis. Myoepithelial cells in breast and salivary gland are also stained. Some recent studies suggest that it is a more specific test than SMA for diagnosing autoimmune liver disease, with about 52% to 85% of those affected having the anti-F-actin antibody. Although this patient has a positive anti-smooth muscle antibody test, the low titer alone is not diagnostic of autoimmune hepatitis. Moderate alcohol consumption ‘should not be recommended for health reasons’. A blood sample is needed. The doctor’s office sends the blood sample to a lab. The technician will send the vial of blood to a laboratory. ab5694 reacts with tumors arising from smooth muscles and myoepithelial cells. Feedback. Your search returned 56 ASMA ELISA ELISA Kit . It is also expressed in the parenchyma and stroma of various . Anyone who has a bleeding disorder or is taking blood thinners should let the technician know in advance. How the Test is Performed. The actin antibody can prove helpful for helping physicians identify a variety of muscular cancers and neoplasms, including pleomorphic adenomas, leiomyosarcomas, and leiomyomas. In this article, we take a close look at the ASMA test, including its uses, the procedure, and how to interpret the results. Anti-smooth muscle antibody (ASMA) is formed against smooth muscle. Anti- smooth muscle antibodies are usually associated with liver damage. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. This antibody was raised against the N-terminal synthetic decapeptide of alpha-smooth muscle actin coupled to keyhole limpet haemocyanin (KLH). This antibody is neither organ nor species specific and does not cross-react with cardiac or skeletal muscle. [3], "Immunoglobulin deposition in liver of patients with active chronic hepatitis and antibody against smooth muscle", https://en.wikipedia.org/w/index.php?title=Anti-smooth_muscle_antibody&oldid=746807318, Creative Commons Attribution-ShareAlike License, This page was last edited on 29 October 2016, at 17:59. Protein Names. For example, they may also order an F-actin antibody test to check for antibodies that can indicate hepatitis. The production of smooth muscle or actin antibodies is strongly associated with . Monoclonal Anti-Actin, α-Smooth Muscle, SMA. 2, 2010 CHAPMAN ET AL. Positivity for anti-nuclear (ANA) and/or anti-smooth muscle (SMA) autoantibodies defines AIH type 1 (AIH-1), whereas anti-liver kidney microsomal type 1 (anti-LKM1) and/or anti-liver cytosol type 1 (anti-LC1) define AIH type 2 (AIH-2). First Name. HELP anti smooth muscle antibody #positive Follow Posted 6 years ago, 4 users are following. The liver mitochondrial antibody is generally absent in drug-induced cholestatic jaundice, viral hepatitis, sclerosing cholangitis, alcoholic and other forms of cirrhosis, hepatic malignancy, and other immune diseases. Anti-smooth muscle antibody. Anticuerpo antimúsculo liso. SMAs attack smooth muscle tissues in the liver and other parts of the body. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. There are several autoantibodies associated with AIH, although the most common is anti-smooth muscle antibody (anti-SMA). The other actins, such as beta- and gamma-cytoplasmic, striated muscle and myocardium . If the smooth muscle antibody (SMA) screen is equivocal or . Doctors consider the ASMA test a low-risk procedure. Anti-smooth muscle antibody. All Rights Reserved. Anti-Alpha smooth muscle Actin antibodies can be readily obtained from commercial sources. Long-term and scalable supply - powered by recombinant technology for fast production. How the Test is Performed. The ASMA test can help a doctor determine whether a person has a disease that damages the liver, such as autoimmune hepatitis, primary biliary cirrhosis, or primary sclerosing cholangitis. The antibody is useful in making a diagnosis of autoimmune hepatitis. testing to when the result is released to the ordering provider. Actin (Smooth Muscle) Antibody (IgG) - Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. The Alpha smooth muscle Actin protein is a reported synonym for the human gene ACTA2, encoding actin alpha 2, smooth muscle. Not all smooth muscle positive samples will have actin antibodies. The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. © 2004-2021 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. No: The pregnancy is too early that little C caused the miscarriage. 500 Chipeta Way Salt Lake City, UT 84108. nws-obgyn.com. Smooth Muscle Antibody. This protein is a member of the Actin family. Delineates situations when tests are added to the initial order. Smooth Muscle Antibody with Reflex to Titer - Smooth muscle antibodies are detected in 85% of patients with chronic active hepatitis and in less than 50% of patients with primary biliary cirrhosis. Anti-smooth muscle antibody is a blood test that detects the presence of antibodies against smooth muscle. Last medically reviewed on September 21, 2018, A serum albumin test measures the levels of albumin in the blood. The doctor will receive the results from the lab and interpret them, then contact the person for a phone consultation or follow-up appointment. 7% in chronic bronchitis. I've recently had an auto immune screen done and the anti smooth muscle antibody has come back positive at 1:320, should I be worried? The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and quantifying proteins and antigens from various samples. MNT is the registered trade mark of Healthline Media. The SMA testing involves the detection of anti smooth muscle antibody against smooth muscle antibody. This 1A4 antibody is specific for the alpha form of muscle actin only, which is expressed by smooth muscle cells of blood vessels, myofibroblasts, and myoepithelial cells. Anti-smooth-muscle antibody is like ANA (anti-nuclear antibodies) that are produced in a human body when the immune system fails to identify between self and non-self adequately. Anti-Smooth Muscle Actin Antibody (B4) is a mouse monoclonal IgG 1 κ Smooth Muscle Actin antibody, cited in 175 publications, provided at 200 µg/ml. It causes, autoimmune hepatitis and other forms of liver . Dr. Christopher Plummer answered. allowed for additional confirmatory or additional reflex tests. Smooth Muscle Antibody (SMA) is protein which is produced by the body's immune system and is directed against its own cytoskeletal proteins of the smooth muscle. Transient low titre antibodies may occur in other hepatic disorders, alopecia, primary pulmonary hypertension and in viral infections. The etiology and function of these antibodies are unknown. 520173. Anti-smooth muscle antibody is a blood test that detects the presence of antibodies against smooth muscle. Anti-smooth muscle antibodies are present in up to 70% patients with autoimmune chronic active hepatitis and in 25-40% of patients with primary biliary cirrhosis (often together with anti-mitochondrial antibodies). Autoimmune hepatitis can be found in anyone at any age, but mostly women are affected. ASMA ELISA Kits. Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC) Available Conjugates: Unconjugated. Anti-smooth muscle antibodies or also known as immunoglobulins are the antibodies which are formed in order to against the smooth muscles. Autoantibodies in the field of liver disease are mainly classified into two entities: (1) non-organ specific autoantibodies including antinuclear antibodies (ANA), smooth muscle antibodies (SMA), antimitochondrial antibodies (AMA), and antibodies to liver kidney microsome type-1 (LKM-1), (2) liver-specific autoantibodies such as antibodies to . Result Code. The anti-smooth muscle antibody (ASMA) test is used to diagnose autoimmune hepatitis and distinguish it from other causes of liver damage. Antibodies. This antibody reacts with Bovine, Canine, Chicken, Guinea Pig, Human, Pig, Rabbit, Rat. 1 . Also, levels of ASMA can be elevated if a person has hepatitis C, infectious mononucleosis, or certain cancers. Synonyms: anti-Actin antibody, F Actin antibody CPT Code: 86255 Description: Anti-smooth muscle antibody (AMSA) is an autoantibody to cytoskeletal components of smooth muscle - principally actin.Hence it is often referred to as anti-actin antibody. Anti-Smooth Muscle Myosin Heavy Chain Antibody Clone MYH11/923. I recently had a positive ANA 1:80 (nuc pattern) and a positive anti smooth muscle antibody, titre 1:20 I thought the smooth muscle antibody was the same test as the anti-Sm test. ARUP Consult. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin, myogenin are positive. The presence of immune complexes in the patient's sample may produce false positives in this assay. Target-specific ELISA kits are available from a variety of manufacturers and can help streamline your immunodetection experiments. Autoimmune hepatitis is an unresolving inflammation of the liver of unknown etiology that is associated with high concentrations of autoantibodies, pronounced hypergammaglobulinemia and the absence of cholestasis. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Testing Algorithm. Synonyms. anti-smooth muscle antibodies. Read Responses. Need to learn more about your liver? The antibody is useful in making a diagnosis of autoimmune hepatitis. Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls. Autoimmune hepatitis is typically accompanied by higher autoantibody titers and elevated γ-globulin levels. Normally, your immune system makes antibodies to attack foreign substances like viruses and bacteria. Boster Bio Anti-Smooth Muscle Myosin Heavy Chain (SM-MHC) (Leiomyosarcoma & Myoepithelial Cell Marker) MYH11 Monoclonal Antibody catalog # M02422. How the Test is Performed. Labcorp has multiple COVID-19 testing options. Maternal-Fetal Medicine 21 years experience. The etiology and function of these antibodies are unknown. Actins are highly conserved proteins that play a role in cell contractile activity, motility, cytokinesis, and in maintaining cell structure. Not all smooth muscle positive samples will have actin antibodies. Synonyms: anti-Actin antibody, F Actin antibody CPT Code: 86255 Description: Anti-smooth muscle antibody (AMSA) is an autoantibody to cytoskeletal components of smooth muscle - principally actin.Hence it is often referred to as anti-actin antibody. The presence of ASMA in the blood indicates that a person may . However, there are no data demonstrating the clinical significance in patients with normal liver function and few showing positive predictive value for AIH when alanine aminotransferase (ALT) is raised. Appointments must be made at least two hours in advance. The technician will find a suitable vein and rub an antiseptic on the area to clean it. These antibodies are typically associated with autoimmune hepati. Tested in IHC. Anti-smooth muscle antibodies are present in up to 70% patients with autoimmune chronic active hepatitis and in 25-40% of patients with primary biliary cirrhosis (often together with anti-mitochondrial antibodies). Order Loinc. Alternative Name: Description: A rather non-specific test. Anti-alpha smooth muscle Actin Antibody (A82445) - Negative Control showing staining of paraffin embedded Human Lung, with no primary antibody. Anti Smooth Muscle Antibody Test in Vineland, New Jersey Same day and Affordable Anti Smooth Muscle Antibody Test, Locations Nationwide.

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